Matrix-Embedded Cells: Matrix-Embedded Endothelial Cells Attain a Progenitor-Like Phenotype (Adv. Biosys. 9/2017)
نویسندگان
چکیده
منابع مشابه
Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells.
The bone marrow (BM) niche comprises multiple cell types that regulate hematopoietic stem/progenitor cell (HSPC) migration out of the niche and into the circulation. Here, we demonstrate that osteocytes, the major cellular component of mature bone, are regulators of HSPC egress. Granulocyte colony-stimulating factor (G-CSF), used clinically to mobilize HSPCs, induces changes in the morphology a...
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Sepsis and its complications are associated with poor clinical outcomes. The circulatory system is a well-known target of lipopolysaccharide (LPS). Recently, several clinical studies documented mobilization of endothelial progenitor cells (EPCs) during endotoxemia, with the probability of patients' survival correlating with the rise in circulating EPCs. This fact combined with endotoxemia-induc...
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Cell function is profoundly affected by the geometry of the extracellular environment confining the cell. Whether and how cells plated on a two-dimensional matrix or embedded in a three-dimensional (3D) matrix mechanically sense the dimensionality of their environment is mostly unknown, partly because individual cells in an extended matrix are inaccessible to conventional cell-mechanics probes....
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ژورنال
عنوان ژورنال: Advanced Biosystems
سال: 2017
ISSN: 2366-7478
DOI: 10.1002/adbi.201770069